KSM-66® is a patented ashwagandha root extract produced by Ixoreal Biomed using a proprietary water-based extraction process (without alcohol) that preserves the complete root profile. It is standardized to a minimum of 5% withanolides, the steroidal lactones responsible for ashwagandha’s adaptogenic, cortisol-modulating, and testosterone-supporting properties in research. KSM-66® has more published human clinical trials than any other ashwagandha extract. At 600 mg per serving, it delivers the dose used in the majority of those trials.*

Vitamin D3 at 20 mcg (100% DV) provides the most bioavailable form of supplemental Vitamin D. Cholecalciferol, at a full daily value dose. Vitamin D is a steroid hormone precursor involved in immune function, testosterone regulation, calcium absorption, mood, and energy metabolism. Deficiency is common and associated with fatigue and reduced vitality, making it directly relevant to the formula’s energy and overall wellness positioning.*

Vitamin B6 is a required cofactor for dopamine, serotonin, and GABA synthesis, three neurotransmitters directly relevant to energy, mood, and stress resilience. Vitamin B12 as Methylcobalamin is the most bioactive B12 form, co-enzymated and ready for cellular use without conversion. At 1,042% DV, the high B12 dose reflects the passive absorption strategy common in B12 supplements. Together B6 and B12 support the neurological and metabolic dimensions of the formula’s energy and vitality positioning.*

L-Arginine is the direct dietary substrate for nitric oxide synthase (NOS), the enzyme that converts arginine to nitric oxide in vascular endothelial cells. Nitric oxide supports vascular smooth muscle relaxation and healthy blood flow, contributing to the physical energy and vitality dimensions of the formula. At 300 mg, it provides a supporting arginine dose alongside the adaptogenic botanicals. L-Arginine may interact with blood pressure medications, PDE5 inhibitors (sildenafil, tadalafil), and blood-thinning medications, consult your healthcare provider before use if you take any of these.*

Maca (Lepidium meyenii) is a Peruvian root vegetable from the high Andes, traditionally consumed as a food and tonic herb for stamina, libido, and reproductive vitality. Its primary bioactives are glucosinolates and macamides, compounds studied for their role in supporting hormonal balance, physical endurance, and libido in men and women. Research has examined Maca for sexual function, energy, and mood in both perimenopausal women and healthy men. It is not a phytoestrogen.*

Panax Ginseng (Asian Ginseng) root is one of the most studied adaptogenic botanicals globally, valued for its ginsenoside content, triterpenoid saponins studied for energy, cognitive function, immune modulation, and physical performance support. Panax Ginseng has a distinct mechanism from Ashwagandha (HPA axis vs. ginsenoside-mediated cellular signaling), making them complementary in an energy and vitality formula. Panax Ginseng interacts with warfarin, MAOIs, stimulant medications, and diabetes medications (insulin, metformin), consult your healthcare provider before use if you take these.*

Shatavari (Asparagus racemosus) is one of the primary Ayurvedic rasayana herbs, rejuvenating tonics for overall vitality and longevity. Its primary bioactives are steroidal saponins (shatavarin I-IV) with mild adaptogenic and estrogenic properties. It is used in traditional practice for both male and female vitality, reproductive health, and immune support. At 50 mg it contributes the Ayurvedic tonic dimension to the formula alongside KSM-66® Ashwagandha and Maca.*